San Antonio Startups to Watch in 2022

By Iris Gonzalez
One caregiver can turn a patient over using a Turn Medical hospital bed. Courtesy photo.

San Antonio’s startup scene is maturing. Local founders are raising more money than ever before, while venture capitalists are paying more attention to our ecosystem, looking for lucrative companies to invest in.

We still have work to do, but take this as a vote for guarded optimism about the state of San Antonio startups. Since we started this list in 2019, our annual compilations (also see our lists from 2020 and 2021) have highlighted startups that are still in the game and growing steadily. Companies on these lists such as FloatMe, Plus One Robotics, and Grain4Grain are scaling operations, hiring talent, and scoring investment dollars. 

Our startup ecosystem reflects innovation across many different fields. You’ll find on the 2022 list more than the expected biomedical, Software-as-a-Service (SaaS), and cybersecurity companies from years past.

We’ve included founders leveraging advanced technologies in robotics, safer battery tech, SaaS platforms for virtual courtroom proceedings, carbon credits that support regenerative agriculture, biomedical devices, augmented reality medical training, and a SaaS platform that streamlines environmental due diligence.


We do not repeat company mentions from year to year, so you’re getting a look at an unranked alphabetical list of startups to watch for growth and potential for impact at scale. These early-stage companies are leveraging innovation with promising early-stage traction and market-product fit to show for their efforts.

These startups are:

  • Privately-owned companies
  • Have revenue potential (if they are pre-revenue)
  • Generate $5 million or less in revenue
  • Employ 50 or fewer employees
  • Have raised Series A or earlier funding rounds
  • Have been in existence for five years or less
Here's our 2022 list of startups in San Antonio you should watch. Share on X

The 2022 San Antonio Startups to Watch

Advanced Surgical Retractor Systems (ASR Systems)

A surgery professor at UT Health San Antonio and former U.S. Navy trauma surgeon developed a new type of surgical retractor, innovating a medical device that hasn’t changed much in over a century.

Read: Advanced Surgical Retractor Systems Innovates 100-Year-Old Medical Device Design

Alt Bionics

Alt-Bionics is a medical device company tackling the unaffordability of high-cost prostheses by delivering affordable alternatives with capabilities that are similar in both form and function to higher-priced devices.

Read: Robotic Prosthetics Startup Alt-Bionics Raises $283K Seed Funding


BEINCOURT offers an end-to-end streamlined platform for conducting virtual court processes with robust virtual capabilities for those who cannot attend a hearing in person.

Read: Legal Tech Startup Creates Platform for Virtual, Hybrid Court Hearings

Grassroots Carbon

Grassroots Carbon is a public benefit limited liability company that provides certified soil carbon storage credits that organizations or individuals can buy to offset greenhouse gas emissions. Grassroots Carbon sells its credits by working with ranchers and farmers using regenerative farming practices that help the soil capture more carbon.

Read: Soilworks Launches Grassroots Carbon, a Carbon Credit Company


MedCognition has a portable system that provides highly-realistic, clinically intuitive medical simulation training.

Read: MedCognition positions for explosive growth in AR medical training

New Dominion Enterprises

Energy technology startup New Dominion Enterprises, Inc. (NDE) is producing additives to make batteries safer and longer-lasting, thanks to Air Force funding to improve the performance of military tactical radios.

Read: New Dominion Enterprises Wins Air Force Phase 2 SBIR Funding for Energy Innovation

Renovo Concepts

Medical device startup Renovo Concepts is developing a way to reduce the damage caused by inflammation setting in after severe traumatic injuries to the brain (TBI) with its Mechanical Tissue Resuscitation (MTR) device.

Read: Renovo Concepts Raises $6.4M Series A Funding for Traumatic Brain Injury Device


Transect streamlines the environmental due diligence process for developers working in the energy, infrastructure, and real estate industries.

Read: Transect helps developers reduce infrastructure project backlog

Turn Medical

Turn Medical is commercializing its automated hospital bed that rotates the patient safely and easily to a prone position onto their abdomen.

Read: Turn Medical Automates Patient Prone Positioning for Critical Care

The featured image is of a single caregiver using a Turn Medical hospital bed to turn a patient over into the prone position. Courtesy photo.

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